What is NAD+?
NAD+, or Nicotinamide Adenine Dinucleotide, is a critical biomolecule that plays a significant role in cellular energy metabolism, redox reactions, and gene expression regulation.
It’s a vital component for life, involved in the energy metabolism, redox reactions, and gene expression control in cells, and is crucial for cell aging regulation and maintaining normal bodily functions.
Why is NAD+ important?
The human body relies on mitochondrial oxidation of nutrients for energy, with NAD+ serving as a crucial catalyst. Without enough catalysts, reactions cannot proceed. NAD+ is present in all living cells, playing an essential role in regulating cell aging and maintaining normal bodily functions.
Over time, aging leads to a significant reduction in NAD+ levels in our bodies. Imagine our bodies as complex machines, with NAD+ being akin to a type of energy battery. This energy battery ensures the smooth operation of various body parts, like keeping our skin, muscles, brain, and other organs healthy. As time goes by, just like any machine that wears out, our bodies also gradually show signs of aging.
A key factor in this process is the declining level of our “energy battery” NAD+, similar to a battery losing its charge.
This decline leads to several issues:
- Insufficient energy supply: Much like how a phone with a low battery struggles to function, a lack of NAD+ can leave us feeling lethargic and stressed.
- Diminished repair capabilities: Comparable to a machine taking longer to fix, our skin, muscles, and other tissues have a harder time healing, leading to wrinkles, accelerated aging, poor sleep quality, declining vision and hearing, muscle loss, and weight gain.
- Weakened immune system: NAD+ is also vital for keeping our immune system in check. A deficiency can weaken it, making us more susceptible to bacterial and viral infections, and leading to poorer health in the liver, kidneys, skeletal muscles, heart, and blood vessels, and increasing the risk of chronic diseases.
- Impaired brain function: Reduced NAD+ levels can affect brain functions, potentially causing depression, memory loss, concentration issues, and cognitive decline.
In essence, as we age and our NAD+ levels decrease, our bodies gradually lose vitality, and various problems can arise, akin to an aging machine starting to malfunction.
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Who is a Good Candidate for NAD+, and what are the benefits of it?
Candidate:
- Individuals who often feel tired or exhausted: Much like charging a phone with a low battery, as energy diminishes with age, NAD+ injections could help the body repair itself, improve sleep quality, and increase overall energy levels.
- Individuals seeking anti-aging and skin rejuvenation benefits: Regular NAD+ injections can enhance cellular regeneration
- Athletes or fitness enthusiasts in need of physical recovery: Whether it's recovering from an injury, surgery, or engaging in high-intensity exercise, NAD+ injections can facilitate faster bodily repair, helping athletes in sports like marathons or triathlons to bounce back to optimal training conditions more swiftly.
- People who often consume alcohol and aim to boost their immunity: NAD+ can aid in metabolizing alcohol and offer some level of liver protection; it can repair genes damaged by acetaldehyde toxins, enhancing the body's resistance to alcohol and boosting immune function.
- Middle-aged and elderly individuals focusing on combating aging and diseases: For those looking to fortify their body against infections and illnesses, increasing NAD+ levels can enhance the health of vital organs such as the liver, kidneys, skeletal muscles, heart, and blood vessels, aiding in disease prevention.
- Individuals experiencing high stress levels or depression: Studies have shown that NAD+ can effectively alleviate symptoms of depression and low mood in the brain, aiding those with depression or substance dependencies in regaining energy and well-being during recovery. Supermodel Kendall Jenner, who has openly discussed her depression, has stated that NAD+ IV injections "made me feel really good and happy."
Can NAD+ help with Alzheimer’s too?
Side Effects and Safety of NAD+ Injections
The most commonly reported adverse effects from administration of intravenous NAD+ are tachycardia, diaphoresis, anxiety, nausea, abdominal discomfort, cramping, fatigue, headaches, and diarrhea. Avoidance of these side effects can be managed by making sure the patient arrives for her treatment well-hydrated, decreasing the dosage of NAD+ administered, and slowing the rate of administration.
In order to minimize side effects, it seems to be generally accepted practice to administer intravenous NAD+ over a minimum of a one-hour period. There are no double-blinded placebo based prospective studies to answer the question you pose. Based on an extensive literature review, best practice appears to be to infuse the baseline starting dose of NAD+ over two hours, and then, if well tolerated, gradually titrate the dose administered upward to maximal effect. At that point, you can experiment with decreasing the infusion time, if desired by the patient. If the starting dosage of intravenous NAD+ is not well tolerated by the patient during or after the infusion, you can decrease the initial dose and/or extend the time of infusion.
While this has not yet been formally studied, at this juncture, there are no known long-term risks of intravenous NAD+ therapy.
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